Slight liver function improvement seen in lipoatrophic diabetes induced by juvenile dermatomyositis
WEDNESDAY, Sept. 20, 2017 (HealthDay News) — Pioglitazone may not be effective for lowering blood glucose levels, although it is associated with slight improvement in liver function, in lipoatrophic diabetes induced by juvenile dermatomyositis, according to a case report published online Sept. 12 in the Journal of Diabetes Investigation.
Yusuke Baba, M.D., from the Chiba University Graduate School of Medicine in Japan, and colleagues present a case of lipoatrophic diabetes induced by juvenile dermatomyositis. A 19-year-old male was admitted for treatment of poorly controlled diabetes; he had been diagnosed with juvenile dermatomyositis at age 3, and was diagnosed with diabetes at age 9.
The authors note that pioglitazone improved liver function slightly, although it was not effective for lowering blood glucose levels, with no change seen in blood glucose and hemoglobin A1c levels. Metreleptin was only administered for a short period, and consequently its effectiveness could not be ascertained. Burned-out nonalcoholic steatohepatitis was revealed on liver biopsy.
“Our results indicate that the successful treatment of lipoatrophic diabetes induced by juvenile dermatomyositis requires an early diagnosis and therapeutic intervention,” the authors write.
Vascular Burden in Midlife Linked to Increased Risk for Dementia, Death 
GLP-1 Receptor Agonists Tied to Increased Risk for Alopecia 
Food-Based Support Aids Type 2 Diabetes Outcomes 
Hypoglossal Nerve Stimulation May Offer Long-Term Cardiovascular Benefits in OSA 
28 Percent of U.S. Adults With HTN Eligible for Treatment Under New Guidelines 
Press-Needle Therapy Shows Potential for Pediatric Allergic Rhinitis 
Burden of Myocardial Dysfunction Elevated for Individuals With Psoriasis 
2017 to 2022 Saw More Than Doubling in Use of GLP-1 Receptor Agonists 
