Here are what the editors at HealthDay consider to be the most important developments in Pathology for May 2020. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.
Physician’s Briefing Weekly Coronavirus Roundup
Here is what the editors at Physician’s Briefing chose as the most important COVID-19 developments for you and your practice for the week of May 25 to 29, 2020. This roundup includes the latest research news from journal studies and other trusted sources that is most likely to affect clinical practice.
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Infection Risk Up in Month After CAR T-Cell Immunotherapy
FRIDAY, May 29, 2020 (HealthDay News) — For children and young adults receiving CD19 chimeric antigen receptor (CAR) T-cell infusion (CTI), infection rates increase in the first month after treatment and then decrease, according to a study published in the May issue of Open Forum Infectious Diseases.
Positive RT-PCR Findings Seen After COVID-19 Discharge
FRIDAY, May 29, 2020 (HealthDay News) — Some patients with COVID-19 have positive reverse transcriptase polymerase chain reaction (RT-PCR) results after discharge, according to a research letter published online May 28 in JAMA Network Open.
Success More Than 50 Percent for Second Child With Fertility Treatment
FRIDAY, May 29, 2020 (HealthDay News) — Women have a good chance of having a second child with the help of assisted reproductive technology (ART), according to a study published online May 8 in Human Reproduction.
CDC: Coronavirus Antibody Tests Still Not Accurate Enough
THURSDAY, May 28, 2020 (HealthDay News) — Coronavirus antibody test results may not be accurate enough to help guide decisions about whether to allow large groups of people to gather at work, schools, dormitories, correctional facilities, and other locations, the U.S. Centers for Disease Control and Prevention said Wednesday.
CBS News Article
More Information: CDC
Genetic Data May Up Diagnostic Efficiency for Rheumatic Disease
THURSDAY, May 28, 2020 (HealthDay News) — Converting genotype information into an interpretable probability value for five different inflammatory arthritis-causing diseases could potentially improve the diagnostic efficiency of rheumatic disease, according to a study published in the May 27 issue of Science Translational Medicine.
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9.5 Percent Uninsured in U.S. From January Through June 2019
WEDNESDAY, May 27, 2020 (HealthDay News) — A total of 9.5 percent of persons were uninsured from January through June 2019, according to a report published online May 28 by the National Center for Health Statistics.
Links Found Between Leaders of Medical Associations, Industry
THURSDAY, May 28, 2020 (HealthDay News) — There are extensive financial relationships between leaders of U.S. professional medical associations and industry, according to a study published online May 27 in The BMJ.
Neurofilament Light Chain Levels Elevated After Repetitive TBI
WEDNESDAY, May 27, 2020 (HealthDay News) — Repetitive mild traumatic brain injuries (mTBI) are associated with elevated exosomal and plasma levels of neurofilament light (NfL) chain, according to a study published online May 27 in Neurology.
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Neuroimaging Features of COVID-19 Are Variable
WEDNESDAY, May 27, 2020 (HealthDay News) — Neuroimaging features of COVID-19 are variable among patients with acute neurological symptoms but are dominated by acute ischemic infarcts, according to a research letter published online May 21 in Radiology.
Early Informed Lung Cancer Patients Have Greater Survival Rates
WEDNESDAY, May 27, 2020 (HealthDay News) — Lung cancer patients who are given the opportunity to be informed of their diagnosis have a longer median survival time, according to a study published in the May issue of Psycho-Oncology.
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Adenovirus Type-5 Vectored COVID-19 Vaccine Shows Promise
TUESDAY, May 26, 2020 (HealthDay News) — A recombinant adenovirus type-5 (Ad5) vectored COVID-19 vaccine is safe, tolerable, and immunogenic, according to a study published online May 22 in The Lancet.
Placental Injury Seen in Pregnant Women With SARS-CoV-2
TUESDAY, May 26, 2020 (HealthDay News) — Higher rates of decidual arteriopathy and other maternal vascular malperfusion features are seen in placentas of women with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), according to a study published online May 22 in the American Journal of Clinical Pathology.
Environmental Chemical Exposure Tied to Kidney Disease in the U.S.
TUESDAY, May 26, 2020 (HealthDay News) — Increased exposure to heavy metal lead, cadmium, or volatile organic compounds may be associated with an increased prevalence of chronic kidney disease (CKD), according to a study published online May 22 in the Clinical Journal of the American Society of Nephrology.
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Platinum Therapy May Up Survival in Pancreatic Cancer With DNA Repair Defects
TUESDAY, May 26, 2020 (HealthDay News) — For patients with advanced-stage pancreatic ductal adenocarcinoma (PDAC), those with homologous recombination deficiency (HRD) have improved survival with first-line (1L) platinum treatment, according to a study published online May 22 in Clinical Cancer Research.
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Physician’s Briefing Weekly Coronavirus Roundup
Here is what the editors at Physician’s Briefing chose as the most important COVID-19 developments for you and your practice for the week of May 18 to 22, 2020. This roundup includes the latest research news from journal studies and other trusted sources that is most likely to affect clinical practice.
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CDC: COVID-19 Not Spread Easily From Contaminated Surfaces
FRIDAY, May 22, 2020 (HealthDay News) — COVID-19 spreads swiftly between people but is not easily caught from contaminated surfaces, according to updated information from the U.S. Centers for Disease Control and Prevention.
Washington Post Article
More Information: CDC
U.S. Offers $1.2 Billion to Drug Company for COVID-19 Vaccine Research
FRIDAY, May 22, 2020 (HealthDay News) — The U.S. Department of Health and Human Services said Thursday it would provide up to $1.2 billion to AstraZeneca to develop a potential COVID-19 vaccine from a lab in Oxford, England.
SARS-CoV-2 Antibodies Detected in 4.65 Percent in Los Angeles County
FRIDAY, May 22, 2020 (HealthDay News) — In recent serologic tests, the weighted prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies was 4.65 percent among adult residents of Los Angeles County, California, after adjustment for test sensitivity and specificity, according to a research letter published online May 18 in the Journal of the American Medical Association.
Clinical Genetic Testing for Autism Remains Very Low
FRIDAY, May 22, 2020 (HealthDay News) — Only 3 percent of patients with autism spectrum disorder (ASD) report having received all recommended clinical genetic testing, according to a research letter published online May 13 in JAMA Psychiatry.
CDC Says Test All Newborns of Mothers With Confirmed, Suspected COVID-19
THURSDAY, May 21, 2020 (HealthDay News) — All babies born to women with confirmed or suspected COVID-19 should be tested, according to U.S. Centers for Disease Control and Prevention guidelines issued Wednesday.
CNN Article
More Information: CDC
Convalescent Plasma Trial for COVID-19 Patients Underway at NYU Langone
THURSDAY, May 21, 2020 (HealthDay News) — Researchers at the NYU Grossman School of Medicine are conducting a phase II clinical trial to determine the efficacy of convalescent plasma in hospitalized patients with COVID-19. Corita R. Grudzen, M.D., vice chair for research in the Ronald O. Perelman Department of Emergency Medicine at NYU Langone Health, wrote the study protocol and recently spoke with HealthDay Live! about the trial.
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NYU Langone Health Press Release
Risk for Autism Spectrum Disorder Up With Affected Aunt, Uncle
THURSDAY, May 21, 2020 (HealthDay News) — The risk for autism spectrum disorder (ASD) is increased for children with an aunt or uncle with ASD, according to a study recently published in Biological Psychiatry.
Clinical Performance of SARS-COV-2 Antibody Tests Varies
THURSDAY, May 21, 2020 (HealthDay News) — The diagnostic specificity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serologic assays varies, and sensitivity is poor during the first 14 days of symptoms, according to a study published online May 13 in Clinical Chemistry.
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Plasma NfL Level Tied to Risk for Disability in Multiple Sclerosis
WEDNESDAY, May 20, 2020 (HealthDay News) — Elevated plasma neurofilament light chain (pNfL) levels are associated with an increased risk for reaching sustained disability worsening in multiple sclerosis (MS), according to a study published online May 20 in Neurology.
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Some Children With COVID-19 Require Admission, PICU Care
WEDNESDAY, May 20, 2020 (HealthDay News) — Some children with COVID-19 require admission and intensive care, according to a study published online May 11 in The Journal of Pediatrics.
Sales of Johnson’s Baby Powder Halted in U.S., Canada
WEDNESDAY, May 20, 2020 (HealthDay News) — Lawsuits claiming that talc-based Johnson’s Baby Powder has caused cancer have led to a plunge in sales in the United States and Canada, so Johnson & Johnson said Tuesday it is ending sales of the product in those two countries.
Multiple Genes Predispose Black Women to Breast Cancer
WEDNESDAY, May 20, 2020 (HealthDay News) — Multiple genes predispose African-American (AA) women to breast cancer, including BRCA1, BRCA2, and PALB2, according to a study published online May 19 in the Journal of the National Cancer Institute.
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11.2 Percent of Pediatric Cancer Patients Positive for SARS-CoV-2
WEDNESDAY, May 20, 2020 (HealthDay News) — Among pediatric cancer patients, overall morbidity of COVID-19 is low, according to a research letter published online May 13 in JAMA Pediatrics.
Spending on Primary Care Continues to Lag in the U.S.
TUESDAY, May 19, 2020 (HealthDay News) — Spending on inpatient services, specialty care, and prescriptions together accounted for about two-thirds of the increase in total U.S. health care spending from 2002 to 2016, according to a research letter published online May 18 in JAMA Internal Medicine.
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Burnout Comparable Between Millennial, Gen X Residents, Fellows
TUESDAY, May 19, 2020 (HealthDay News) — Millennial and Generation X medical residents and fellows experience similar rates of burnout and have similar levels of empathy, according to a study published online May 5 in Academic Psychiatry.
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Higher Burden of Cardiovascular Risk Tied to Cognitive Decline
TUESDAY, May 19, 2020 (HealthDay News) — Higher cardiovascular risk burden is associated with cognitive decline and neurodegeneration, according to a study published in the May 26 issue of the Journal of the American College of Cardiology.
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Cord Blood Does Not Improve Socialization Skills in Autism
TUESDAY, May 19, 2020 (HealthDay News) — A single infusion of cord blood (CB) does not improve socialization skills or reduce autism symptoms among children with autism spectrum disorder (ASD), according to a study published online May 19 in The Journal of Pediatrics.
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Experimental COVID-19 Vaccine Appears Safe, Triggers Immune Response
MONDAY, May 18, 2020 (HealthDay News) — An experimental vaccine against COVID-19 appears to be safe and to trigger an immune response, according to results of the first human clinical trial of a COVID-19 vaccine.
Social Distancing Policies Reduced COVID-19 Growth Rate
MONDAY, May 18, 2020 (HealthDay News) — The impact of four widely adopted social distancing policies reduced the daily growth rate of COVID-19 across U.S. counties, according to a report published online May 14 in Health Affairs.
Most Physicians Have Seen False-Negative COVID-19 Test Results
MONDAY, May 18, 2020 (HealthDay News) — Most physicians believe they have seen false-negative results for a COVID-19 diagnostic test, according to the results of a recent survey.
Cough May Not Appear in Young Children With COVID-19
MONDAY, May 18, 2020 (HealthDay News) — Young children with COVID-19 may not present with respiratory symptoms, according to a case report published online May 12 in Frontiers in Pediatrics.
Convalescent Plasma Appears Promising for Severe COVID-19
MONDAY, May 18, 2020 (HealthDay News) — Administration of convalescent plasma seems safe and results in improvement in clinical status for patients with severe or life-threatening COVID-19, according to a study not yet peer reviewed and posted on medRxiv.org.
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Physician’s Briefing Weekly Coronavirus Roundup
Physical Therapist-Supervised Exercise Improves Outcomes After ACL Reconstruction 
Early Complications Common in Older Kidney Transplant Recipients 
PET/MRI Offers Diagnostic, Prognostic Value in Pediatric Epilepsy 
Less Intraoperative Crystalloid Fluid Not Tied to Worse Surgical Outcomes 
Socioeconomic Status Linked to Mortality After Acute Hip Fracture Surgery 
Relapse Rare After Appendiceal Adenocarcinoma Resection 
Disparities Identified in Home Health Care After Hip, Knee Replacement 
Preoperative IV Iron Beneficial for Patients With Anemia Undergoing Cardiac Surgery 
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