Age, Disease Duration Are Predictors of CKD After Stem Cell Transplant

TUESDAY, Aug. 12, 2025 (HealthDay News) — Predictors of chronic kidney disease (CKD) include age and hematologic disease length after hematopoietic stem cell transplantation (HSCT), according to a study published online Aug. 4 in Renal Failure.

Alina Tanase, M.D., Ph.D., from Fundeni Clinical Institute in Bucharest, Romania, and colleagues prospectively assessed a cohort of 197 patients (mean age, 38.7 years; 52.8 percent female) who underwent allogeneic HSCT to explore the incidence and risk factors associated with CKD.

Overall, acute kidney injury was present in 80 percent of patients within three months, and CKD incidence was 11.7 percent (median onset, six months). The researchers found that age (per one year) was the only variable associated with CKD by univariate Cox regression analysis (hazard ratio [HR], 1.06); a trend of association was presented for baseline creatinine (per 1 mg/dL). Positive predictors for CKD included age (per one year; HR, 1.08) and hematologic disease length (per one month; HR, 1.01) in a multivariate Cox regression analysis. Acute lymphoblastic leukemia was a negative predictive factor (HR, 0.37).

“Given the continuously improving oncologic prognosis of these patients, CKD is becoming a challenge in the long-term care after HSCT, compelling for a multidisciplinary approach,” the authors write.

Abstract/Full Text