Life”s Crucial 9 Negatively Linked to Overactive Bladder

WEDNESDAY, Feb. 5, 2025 (HealthDay News) — Life”s Crucial 9 (LC9), a recently proposed method for assessing cardiovascular health, has a strong negative correlation with overactive bladder (OAB), which is partially mediated by the weight-adjusted waist index (WWI), according to a study published online Jan. 5 in Frontiers in Nutrition.

Hongyang Gong, from the Fuzhou Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine in China, and colleagues examined the relationship between LC9 and OAB using data from the National Health and Nutrition Examination Survey and then examined whether WWI moderates the association.

The study included 25,319 participants, 5,038 of whom reported incidents of OAB. The researchers found that after multivariable adjustment, a 10-unit increase in LC9 was associated with a significant reduction in OAB (odds ratio, 0.72), while an increase of 1 unit in WWI was associated with a significantly increased risk for OAB (odds ratio, 1.40). When LC9 and WWI were categorized into quartiles, consistent results were seen. A linear negative correlation between the incidence of OAB and LC9 was indicated in a restricted cubic splines analysis. WWI mediated 13.89 percent of the relationship between LC9 and OAB.

“Our study provides new insights into the prevention and management of OAB, emphasizing that a comprehensive approach to improving cardiovascular health and addressing obesity may help reduce the prevalence of OAB,” the authors write.

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