Men present at a younger mean age than women; 40.4 percent of men present before 60 years of age
FRIDAY, March 6, 2026 (HealthDay News) — Features that characterize presentation of vitreoretinal lymphoma are described in an article published online March 1 in Clinical & Experimental Ophthalmology.
Mara Albert-Fort, M.D., Ph.D., from Doctor Peset University Hospital in Valencia, Spain, and colleagues used data from the International Vitreoretinal B-Cell Lymphoma Registry to analyze demographics, tumor features, optical coherence tomography (OCT) signs, and visual acuities among 57 men and 81 women with vitreoretinal lymphoma.
The researchers found that men presented at a younger mean age than women, with 40.4 and 21.0 percent, respectively, presenting before age 60 years. In 80.4 percent, diagnosis was by cell-based and molecular tests on ocular samples, while in 19.6 percent, diagnosis was from indirect clinical evidence. Lymphoma type was diffuse large B-cell in 99.0 percent, if known. In 65.0 percent of patients, the tumor was bilateral and involved the vitreous and retina in 90.6 and 60.1 percent, respectively. Extraocular tissues were concurrently involved in 26.8 percent: within the central nervous system and outside in 23.2 and 5.1 percent, respectively. Overall, 96.4 percent of patients had ocular imaging by OCT; 80.5 percent had abnormalities, including subretinal and sub-retinal pigment epithelial nodules. There was wide variation seen in Snellen visual acuity for 227 eyes, with a median of 6/12. Visual acuities were ≥6/12, <6/19, and ≤6/60 in 54.6, 33.0, and 22.9 percent of eyes, respectively.
“Delayed diagnosis of this eye cancer can carry serious consequences, but our findings offer practical information that will help clinicians consider the disease earlier,” coauthor Justine Smith, M.B.B.S., Ph.D., from Flinders University in Adelaide, Australia, said in a statement.
Subset of Patients With Follicular Lymphoma Can Achieve Cure With CHOP-Based Chemoimmunotherapy 
Physicians Have Modestly Higher Likelihood of Dying at Home or Hospice 
New-Onset Mental Health Issue After Cancer Diagnosis Tied to Higher Risk for Death 
Living in Closer Proximity to Nuclear Power Plants May Increase Cancer Mortality Risk 
Physical Activity May Reduce Risk for Death From Cancer 
Short-Term Surgical Outcomes at Rural Facilities Similar to Those in More Distant, Urban Facilities 
Updated Pan-Tumor Guidelines Issued for Assessing Pathologic Response 
Mortality Increased With Ultraprocessed Food Consumption After Cancer Diagnosis 
