Association remains regardless of the presence of most other risk factors for ovarian cancer
FRIDAY, Aug. 12, 2022 (HealthDay News) — Frequent aspirin use is associated with lower ovarian cancer risk regardless of the presence of most other ovarian cancer risk factors, according to a meta-analysis published online July 22 in the Journal of Clinical Oncology.
Lauren M. Hurwitz, Ph.D., from the National Cancer Institute in Rockville, Maryland, and colleagues used individual-level data from 17 studies to examine the association between frequent aspirin use and ovarian cancer risk.
Based on nine cohort studies from the Ovarian Cancer Cohort Consortium (2,600 cases) and eight case-control studies from the Ovarian Cancer Association Consortium (5,726 cases), the researchers found that frequent aspirin use was associated with a 13 percent reduction in ovarian cancer risk, with no significant heterogeneity by study design or histotype. This association was not seen among women with endometriosis; however, consistent risk reductions were seen among all other subgroups defined by ovarian cancer risk factors, including women with two or more risk factors (relative risk, 0.81).
“Risk reductions were also observed among women with multiple risk factors, providing proof of principle that chemoprevention programs with frequent aspirin use could target higher-risk subgroups,” the authors write.
Several authors disclosed financial ties to pharmaceutical companies, including Bayer.