Infectious Diseases Society of America, Oct. 11-15

The annual meeting of the Infectious Diseases Society of America was held this year from Oct. 11 to 15 in Boston and attracted participants from around the world, including scientists, physicians, and other health care professionals. The conference featured education courses and comprehensive educational programs that focused on the latest advances in the diagnosis, treatment, and prevention of infectious diseases. The meeting also provided insight into emerging infections, new diagnostics, vaccines, and therapeutic interventions.

In one study, Amy W. Law, Pharm.D., of Pfizer Inc. in New York City, and colleagues found that maternal immunization is an attractive strategy to actively immunize pregnant individuals to passively protect their newborns and young infants during their vulnerable first months of life.

The authors shared the results from a cohort model developed to assess the impact of maternal vaccination with the Pfizer respiratory syncytial virus (RSV) vaccine (RSVpreF) among infants from birth to age 1 year. In the absence of vaccination, 592,000 cases of RSV-lower respiratory tract disease (LRTD) occur annually among infants, with a corresponding total economic cost of $1.7 billion. The researchers found that maternal vaccination with RSVpreF between 32 and 36 weeks of gestation has the potential to prevent more than 195,000 cases of RSV-LRTD and reduce associated costs by 45 percent. In addition, the model indicated that 23,519 hospitalizations could be avoided, another $667 million in total direct costs could be averted, and $107 million in total indirect costs could be averted.

“Globally, RSV is the leading viral cause of lower respiratory tract infection, including bronchiolitis, and by extension, the leading cause of infant hospitalization outside of birth hospitalization,” Law said. “And now, a maternal RSV vaccine for pregnant people during 32 through 36 weeks gestation, using seasonal administration, is available to prevent RSV lower respiratory tract infection in infants.”

Law is an employee of Pfizer, which manufactures the RSVpreF vaccine.

Press Release

Johanna Kaufmann, Ph.D., of Codagenix in Farmingdale, New York, and colleagues found that CoviLiv, a novel intranasally delivered live-attenuated COVID-19 vaccine, is safe and induces a robust systemic immune response directed against the spike protein, like authorized mRNA vaccines, but also other proteins in the viral genome that are known to mutate less frequently than spike.

The authors described the immune response observed in a first-in-human placebo-controlled dose-escalation trial testing safety and immunogenicity of one or two doses of intranasally delivered CoviLiv, conducted in healthy young adults who had not been previously vaccinated or had known or suspected prior infection with severe acute respiratory syndrome coronavirus 2. The data focused on the highest tested dose group and the primary observation period of 57 days after the first dose.