The medical records from a large database were assessed to identify patients who had surgery with anesthesia between 2014 and 2023. The researchers found that NSAIDs like ibuprofen reduced the incidence of postoperative delirium more than Tylenol when given before, during, or immediately after surgery. Furthermore, nonsalicylates were superior compared with salicylates in reducing the incidence of delirium. The reduction in delirium was most significant in patients older than 65 years, who have a higher risk for delirium due to comorbidities and age.
“We have been increasingly incorporating NSAIDs into our surgical recovery protocols. We routinely use medications like the nonsalicylate NSAID celecoxib for this purpose,” Nicholson said. “Additional research needs to be completed to identify NSAIDs that are most effective, the patient population we should target most, and exact timing of the intervention (pre-, intra-, or postoperative).”
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