The American Heart Association/American Stroke Association International Stroke Conference
Michelle C. Johansen, M.D., Ph.D., of the Johns Hopkins University School of Medicine in Baltimore, and colleagues found that myocardial infarction (MI) is associated with a faster decline in global cognition, memory, and executive function during the years following the event.
The authors evaluated data from participants across six population-based cohort studies with different measures of cognition. The data were harmonized to allow for consistent cognitive measures across all cohorts, and the authors specifically used linear mixed-effects models with time-varying incident MI variable (intercept) and a follow-up time after MI variable (slope) to determine how the cognitive trajectories changed at the time of and after incident MI. The researchers observed little decline in any measure of cognition in the short term after an MI; however, they did observe faster declines in memory, executive functioning, and global cognition in the years following the MI.
“We believe that effective interventions to prevent the initial MI event are likely to reduce the rate of cognitive decline among these individuals,” Johansen said.
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